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static extern uint EnableMenuItem(IntPtr hMenu, uint itemId, uint uEnable);

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    EnableMenuItem(hMenu, 0, MF_BYPOSITION | MF_ENABLED);

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    EnableMenuItem(hMenu, 1002, MF_BYCOMMAND | MF_GRAYED);

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Documentation

[EnableMenuItem] on MSDN

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Summary

The EnableMenuItem API

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static extern bool EnableMenuItem(IntPtr hMenu, uint uIDEnableItem,

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Public Function EnableMenuItem(ByVal hMenu As IntPtr, ByVal wIDEnableItem As UInteger, ByVal wEnable As UInteger) As IntPtr

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Constants used with Add/Check/EnableMenuItem:

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    Private Shared Function EnableMenuItem(ByVal hMenu As IntPtr, ByVal wIDEnableItem As UInteger, ByVal wEnable As UInteger) As IntPtr

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    EnableMenuItem(GetSystemMenu(Me.Handle, False), SC_CLOSE, MF_GRAYED)

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Documentation

[EnableMenuItem] on MSDN